• Introduction
• API Development and Manufacture
  • Medicinal Chemistry Support
  • First in Man (Rapidd™)
  • Intermediate and API Supplies
  • Supporting Capabilities
• Solid State Services
  • Polymorph Screening Service
  • Crystal Engineering
  • Crystal Form Selection
  • Characterisation
  • Pharma Expert Witness
• Analytical
  • Method Development and Validation
  • Physical and Chemical Characterisation
  • Product Testing
  • Stability Testing
  • Facilities and Instrumentation
• Peptides and Proteins
  • GMP Peptide API
  • Custom Peptides
  • Immunograde Peptides
  • Chemokines
  • Site Specific PEGylation
    • Ligation Technology
    • Application to PEGylation
  • Facilities and Equipment
  • Quote
• Isotope Chemistry
  • Chemistry
  • Analysis
  • cGMP
  • Labels
• Biocatalysis
  • Biocatalysis Services
  • Biocatalysis Expertise
  • Enzyme Kits
  • Process Development
  • Chiral Building Blocks
  • Enzyme Screening
  • Fermentation & Molecular Biology
  • Purification
  • Enzyme Kit Quotation Request

Medicinal Chemistry Support

Almac Sciences provides a range of services supporting medicinal chemistry activities during the drug development process. These include:

• Synthesis of scaffolds, building blocks and lead optimisation
  (including catalogue of compounds)
• Route design and synthesis for new target molecules
  
• Synthesis of metabolites, impurities and reference compounds
  
• Comparator support
  
• Peptides
  
• Analysis

Scaffold/Building Blocks/Lead Optimisation
We apply our medicinal chemistry expertise and synthetic capability to deliver diverse scaffolds and libraries. Solution phase parallel synthesis and purification are used to generate focused libraries frequently from complex multi stage syntheses. We create further value through the synthesis of multi-target analogues enhancing library diversity.

Potential NCEs from early programmes can progress to First In Man and beyond using our expertise in route selection, process development, scale up and First In Human activities.

Our extensive synthetic chemistry expertise is the platform from which we work to solve our customers’ synthetic challenges. Examples of our chemistry expertise include:

• Chiral chemistry
• Diazo chemistry
• Organophosphorus chemistry

Metabolites, Impurities and Reference Compounds
Through our synergistic/connected services of analysis, chemistry and isotopic labelling we identify, synthesise and confirm the structure of the metabolites generated from your drug, providing valuable information to support ADME studies.

Almac Sciences routinely synthesises and characterises impurities and reference compounds to provide early/timely and rapid information about the quality of your pre-clinical API.

Analytical
Our extensive in-house analytical capabilities are key in supporting your pre-clinical needs.